NAPLEX (North American Pharmacist Licensure Examination) Practice Exam 2025 - Free NAPLEX Practice Questions and Study Guide

The recommended combination of drugs for MAC (Mycobacterium avium complex) treatment in HIV includes clarithromycin or azithromycin in combination with ethambutol. This combination is the standard treatment regimen for MAC infection. Clarithromycin or azithromycin are macrolide antibiotics that are active against MAC. Ethambutol is another antimycobacterial agent that is often used in combination with a macrolide to treat MAC infections.

Option A (Valganciclovir + ganciclovir) is incorrect because these are antiviral medications used to treat cytomegalovirus (CMV) infections, not MAC.

Option B (Bactrim + prednisone) is incorrect because although Bactrim (sulfamethoxazole/trimethoprim) can be used for prophylaxis against MAC in HIV patients, prednisone is not part of the standard MAC treatment regimen.

Option D (Amphotericin B + flucytosine) is incorrect because these medications are used to treat fungal infections, such as cryptococcal meningitis, and are not part of the standard treatment for MAC in HIV.