NAPLEX (North American Pharmacist Licensure Examination) Practice Exam 2025 - Free NAPLEX Practice Questions and Study Guide

Question: 1 / 1820

What class of antibiotics inhibits folic acid synthesis?

Aminoglycosides

Sulfonamides

Sulfonamides inhibit folic acid synthesis by acting as competitive inhibitors of the enzyme dihydropteroate synthase. This enzyme is involved in the synthesis of folic acid, an essential component in bacterial DNA synthesis. By blocking this enzyme, sulfonamides prevent the production of folic acid, leading to a disruption in bacterial growth and replication.

Aminoglycosides (Option A) inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit. Cephalosporins (Option C) and Penicillins (Option D) are beta-lactam antibiotics that interfere with bacterial cell wall synthesis by targeting the enzymes responsible for building and maintaining the cell wall.

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Cephalosporins

Penicillins

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