NAPLEX (North American Pharmacist Licensure Examination) Practice Exam 2025 - Free NAPLEX Practice Questions and Study Guide

Beta-3 agonists for overactive bladder (OAB) primarily work by relaxing the detrusor muscle in the bladder. By activating beta-3 receptors in the bladder, these medications help to increase bladder capacity and reduce the urgency and frequency of urination. Relaxing the detrusor muscle allows the bladder to hold more urine, leading to improvements in OAB symptoms such as urinary urgency, frequency, and urge incontinence.

Option A is incorrect because beta-3 agonists actually reduce the frequency of urination by increasing bladder capacity, rather than increasing urination. Option C is incorrect because beta-3 agonists do not induce sleep; their mechanism of action is specifically related to the detrusor muscle in the bladder. Option D is incorrect because beta-3 agonists do not increase blood pressure; instead, they target beta-3 receptors in the bladder to improve symptoms of OAB without affecting blood pressure.