NAPLEX (North American Pharmacist Licensure Examination) Practice Exam 2025 - Free NAPLEX Practice Questions and Study Guide

Question: 1 / 1820

What formula is used to calculate the loading dose (LD) of a drug?

(2 x diastolic pressure) + systolic pressure / 3

total phenytoin measured / (0.2 x albumin) + 0.1

0.693/ke

(Desired concentration x Vd) / F

To calculate the loading dose (LD) of a drug, the formula used is (Desired concentration x Vd) / F.

This formula takes into account the desired plasma concentration of the drug (desired concentration), the volume of distribution (Vd), and the bioavailability of the drug (F). By using this formula, pharmacists can determine the initial dose of a drug needed to achieve the desired plasma concentration rapidly.

The other options are incorrect:

A. (2 x diastolic pressure) + systolic pressure / 3 - This formula does not relate to calculating the loading dose of a drug.

B. total phenytoin measured / (0.2 x albumin) + 0.1 - This formula is specific to calculating the corrected phenytoin level and is not used for calculating the loading dose of a drug.

C. 0.693/ke - This formula is related to drug elimination half-life calculation and is not used for determining the loading dose of a drug.

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