NAPLEX (North American Pharmacist Licensure Examination) Practice Exam 2025 - Free NAPLEX Practice Questions and Study Guide

Sulfasalazine is the correct answer because it can cause yellow-orange coloration of the skin and urine. This discoloration is due to the drug's metabolite, sulfapyridine, which can accumulate in the body and manifest as this unique side effect. It is important for healthcare providers to be aware of this potential adverse effect when prescribing sulfasalazine to patients with rheumatoid arthritis or other conditions requiring Disease-Modifying Antirheumatic Drugs (DMARDs).

Regarding the other options:

- MTX (Trexall) is a DMARD commonly used in the treatment of rheumatoid arthritis, but it does not typically cause yellow-orange coloration of the skin or urine.

- Hydroxychloroquine is another DMARD that is less likely to cause yellow-orange discoloration compared to sulfasalazine.

- Leflunomide is a DMARD that is associated with adverse effects such as hepatotoxicity and bone marrow suppression, but not yellow-orange skin or urine discoloration.