NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a contraindication for using Rolumilast in COPD treatment?

Light smoking history
Moderate to severe liver impairment
Use of inhaled corticosteroids
Previous use of antibiotics for COPD exacerbations

The correct answer is: Moderate to severe liver impairment

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor used in the treatment of chronic obstructive pulmonary disease (COPD). One of the contraindications for using roflumilast is moderate to severe liver impairment. This is because roflumilast is metabolized in the liver, so patients with significant liver dysfunction may not be able to properly metabolize the drug, leading to potential toxicity. Therefore, patients with moderate to severe liver impairment should not be prescribed roflumilast to avoid potential harm. Conversely, the other options such as having a light smoking history, use of inhaled corticosteroids, or previous use of antibiotics for COPD exacerbations are not contraindications for using roflumilast in COPD treatment.