NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Prepare for the NAPLEX (North American Pharmacist Licensure Examination) Test. Study with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

Each practice test/flash card set has 50 randomly selected questions from a bank of over 500. You'll get a new set of questions each time!

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What is the maximum dose of Simvastatin when taken with amiodarone?

20 mg
40 mg
10 mg
5 mg

The correct answer is: 20 mg

When Simvastatin is taken with amiodarone, which is known to interact with statins, there is a significant risk of myopathy and rhabdomyolysis. Therefore, the maximum recommended dose of Simvastatin when taken with amiodarone is 20 mg to reduce this risk. Higher doses of Simvastatin can increase the likelihood of severe muscle-related side effects when combined with amiodarone. This recommendation is crucial in optimizing patient safety and preventing harmful drug interactions. Options B, C, and D are incorrect as they suggest doses that exceed the recommended maximum of 20 mg when Simvastatin is used concurrently with amiodarone, thereby increasing the risk of adverse effects.