NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication for BPH may cause orthostatic hypotension/syncope?

  1. Selective alpha-1A blockers

  2. 5-alpha reductase inhibitors

  3. Beta-3 receptor agonists

  4. PDE-5 inhibitors

The correct answer is: Selective alpha-1A blockers

Selective alpha-1A blockers are the only medication listed that have the potential to cause orthostatic hypotension/syncope, as they can lower blood pressure and cause lightheadedness or fainting upon standing. 5-alpha reductase inhibitors, beta-3 receptor agonists, and PDE-5 inhibitors do not have this side effect and are not typically used for the treatment of BPH.

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