NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Prepare for the NAPLEX (North American Pharmacist Licensure Examination) Test. Study with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

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Which medication is NOT a 5-HT3-RA?

Ondansetron
Granisetron
Palonosetron
Aprepitant

The correct answer is: Aprepitant

Ondansetron, Granisetron, and Palonosetron are all 5-HT3 receptor antagonists (5-HT3-RAs) which are commonly used to prevent nausea and vomiting. These medications work by blocking the action of serotonin, a chemical in the body that can trigger nausea and vomiting. However, Aprepitant is not a 5-HT3-RA, it is a neurokinin-1 (NK-1) receptor antagonist, which works differently by blocking the action of substance P in the brain. Aprepitant is also commonly used to prevent nausea and vomiting caused by chemotherapy. Therefore, it is the only option that is not a 5-HT3-RA.